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X-WR-CALDESC:Events for Castro and Lowenstein Lab
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DTSTART:20240101T000000
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DTSTART;TZID=UTC:20250316T080000
DTEND;TZID=UTC:20250321T170000
DTSTAMP:20260419T093213
CREATED:20250207T170409Z
LAST-MODIFIED:20250207T170409Z
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SUMMARY:Joint March Meeting and April Meeting: Global Physics Summit 2025
DESCRIPTION:We are excited to share that the 2025 Joint March Meeting and April Meeting will now be called the APS Global Physics Summit. This event is the largest physics research conference in the world\, uniting 14\,000 members of the scientific community across all disciplines of physics. \nBoth in-person and virtual presentation and registration options are available. \nRegister/Housing Here
URL:https://lowenstein-castrolab.com/event/joint-march-meeting-and-april-meeting-global-physics-summit-2025/
LOCATION:Anaheim\, CA
ATTACH;FMTTYPE=image/png:https://lowenstein-castrolab.com/wp-content/uploads/2025/02/download-1.png
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DTSTART;TZID=UTC:20250318T161200
DTEND;TZID=UTC:20250318T162400
DTSTAMP:20260419T093213
CREATED:20250207T171218Z
LAST-MODIFIED:20250207T171218Z
UID:1030-1742314320-1742315040@lowenstein-castrolab.com
SUMMARY:Dr. Pedro Lowenstein and Ph.D. Student Anna Argento Speaking at APS Global Physics Summit
DESCRIPTION:3D nematic organization and topological defects in brain tumors in vivo.\nPresented by Pedro Lowenstein (University of Michigan) \nGlioblastomas (GBM) are the most common adult brain tumors\, characterized by rapid invasion into the normal brain and therapeutic resistance. We previously demonstrated that GBM tumors exhibit self-organized\, nematically aligned\, multicellular structures\, termed “oncostreams\,” that influence tumor invasion and malignancy. Here we show the presence of topological defects in glioma cells in-vitro (2D) and tumors in-vivo (3D). To understand nematic organization and topological defects within gliomas in 3D\, we utilized whole brain clearing and light-sheet scanning microscopy to image tumors with an extremely high resolution (0.5 x 0.5 x 0.5 um). Creating 3D reconstructions and 3D elastic distortion maps allowed us to identify oncostreams (high nematic order domains)\, and to identify topological defects as regions of low nematic order and finite winding number using OpenViewMin. To our knowledge\, this is the first evidence of 3D topological defects in-vivo within tumors and highlights the complex liquid crystalline order of glioblastomas. We believe this new understanding of the structure of glioblastoma organization will lead to the development of therapeutic strategies targeting malignant oncostreams and topological defects. \nAuthors: \n\nPedro Lowenstein (University of Michigan)\nAnna Argento (University of Michigan)\nBinyamin Jacoobovitz (University of Michigan)\nDaniel Beller (Johns Hopkins University)\nMaria Castro (University of Michigan)\nCarles Blanch-Mercader (Institut Curie)
URL:https://lowenstein-castrolab.com/event/dr-pedro-lowenstein-and-ph-d-student-anna-argento-speaking-at-aps-global-physics-summit/
LOCATION:Anaheim\, CA
ATTACH;FMTTYPE=image/jpeg:https://lowenstein-castrolab.com/wp-content/uploads/2024/04/Pedro-headshot-002-002.jpg
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